Leading scientists from Academician Ali Guliyev Institute of Chemistry of Additives of the Ministry of Science and Education of the Republic of Azerbaijan and their colleagues from the Irkutsk Institute of Chemistry of Russia, Ataturk and Bartin Universities of Turkey have obtained further important results in the course of joint international research conducted on the topic of “Synthesis of new highly active derivatives of pyrrole heterocycles as dual inhibitors of acetylcholinesterase (AChE) and α-glycosidase (α-Gly), study of their biological activity in vitro and in vivo.”
According to the information from the Institute’s Public Relations Department, these important results have been archived in the Web of Science database as a detailed research article in the Journal Molecular Structure of the world-famous Elsevier Publishing House with an impact factor of category Q2 4.06 (Olga Vladimirovna Petrova, Denis N. Tomilin, Khalil Senol, Ksenia Vladimirovna Belyaeva, Lina Petrovna Nikitina, Oparina Lyudmila Aleksandrovna, Sobenina Lyubov N., Trofimov Boris Aleksandrovich, Sadegyan Nastaran, Parham Taslimi, Vagif Farzaliev, Afsun Sudjaev, Ilhami Gulchin, Synthesis of pyrrole-heterocyclic derivatives as anti-Alzheimer’s disease and antidiabetic agents: an in vitro in silico study, Journal of Molecular Structure, 2024, 1315, 138998, https://doi .org/10.1016/j.molstruc.2024.138998).
The article notes that AChE and α-Gly enzymes with favorable pharmacokinetic profiles were more effective compared to new generation inhibitor analogues, which showed strong inhibition. Molecular docking, dynamic modeling and prediction of ADME biological activity allowed us to conclude that these compounds have the potential to be selective inhibitors of AChE and α-Gly. In particular, the newly developed inhibitors may help in the near future to develop new biological supplements for the treatment of some of the most common global diseases, including Alzheimer’s disease and diabetes.
