The Institute of Chemistry of Additives regularly hosts events to expand international scientific ties.
As part of an international collaboration with colleagues from Baku Engineering University and various Russian research centers, scientists at the Institute have synthesized new Schiff bases and studied their structural properties in detail. The research results were published in the journal “Molecular Structure” with a Q1 classification and an impact factor of 4.
Joint research with colleagues from Belarus has been ongoing for a long time. Currently, using advanced methods of organic synthesis, the Institute is studying the various functional properties of newly synthesized compounds, their mechanisms of action, developing a scientific basis for selecting promising reagents based on the relationship between their structure and efficacy, evaluating the efficacy of these compounds in animal models, conducting computer calculations of the spectrum of biological activity, and demonstrating the high efficacy of these compounds compared to standard drugs.
The results of a joint international study conducted by a group of leading scientists from the Institute of Chemistry of Additives, Baku State University and Baku Engineering University, together with colleagues from Turkey, were published in the journal “Chemistry and Biodiversity” by the world-renowned Wiley publishing house (https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.202403048).
In collaboration with leading scientists from the Institute of Physical Problems at Baku State University and Allan University in South Carolina (USA), DFT calculations of the formation reactions of several transition metal complexes with thiocarbamide were performed using computational chemistry. The theoretically possible optimal structures were determined, and then experimentally confirmed.
As part of an international collaboration with scientists from Atatürk and Bartin Universities in Turkey, the effects of several new oxiranes and thiiranes, previously synthesized at the institute, on various metabolic enzymes, including acetylcholinesterase and carbonic anhydrase isoenzymes, were assessed. The results demonstrate that the synthesized compounds exhibit high affinity and specificity for the target enzymes, indicating their potential for further development as therapeutic agents. Future research will focus on optimizing the structural features of these compounds to enhance their selectivity and bioactivity, evaluating their pharmacokinetic and pharmacodynamic properties, and exploring their potential use in the treatment of neurodegenerative and metabolic diseases.
A joint research group has been established with researchers from King Said University (Saudi Arabia) on the topic of “Development of Inhibitors with Therapeutic Potential for Neurodegenerative Diseases.” In a joint international study conducted this year with Saleh Alwasel, the head of the Saudi Arabian research team, important results were achieved in the international collaborative research project “Synthesis and Biological Characterization of Novel Acetophenone-Based Chalcone, Semicarbazone, Thiosemicarbazone, and Indolone Derivatives: Structure-Activity Relationships, Molecular Assembly, Molecular Dynamics, and Kinetic Studies.”
These important findings were published as a detailed research article in Molecular Structure, a world-renowned Elsevier journal with an impact factor of Q2 4.0, archived in the Web of Science database. https://www.sciencedirect.com/science/article/pii/S0022286024027066.