Laboratory of Physiologically Active Organic Compounds

Head of the Laboratory

Doctor of Chemical Science


Purposeful synthesis and study of physiologically active and other functional organic compounds


The laboratory has functioned since 1965 – the date of the establishment of academician  A.Guliyev Institute of Chemistry of Additives of ANAS. In different years the laboratory was headed by the Correspondent Member of ANAS Rauf Babakhanov (1965-1969), Academician of ANAS Vagif Farzaliyev (1969-1988) and Doctor of Chemical Science, Professor Mirza Allahverdiyev (1988-2017). Since 2018 the laboraory has been headed by Doctor of Chemical Science, Associate Professor Afsun Sujayev.

The principal direction of the scientific activity of the laboratory consists of systematic research in the field of the synthesis of highly effective antioxidants and physiologically active compounds by using fine organic synthesis and the study of the mechanism of their action, developing the scientific bases of creation of high-performance additives to  lubricating oils and fuels, studying the relationship between their structure, composition and functional properties. The laboratory is engaged in the targeted synthesis of various classes of organic compounds – highly effective additives for lubricating oils and fuels.

It should be noted that studying the action mechanism of additives under the normal working condition of machines and mechanisms is very difficult. Therefore, detailed investigation of the action mechanism of additives and the relationship between their structure and functional features in the laboratory condition is one of the problems to be solved by the investigators.

For a long time in the laboratory there have been implemented the systemized research in the field of the synthesis of different sulfur-organic compounds, their study as anti-wear and anti-scuff additive. For this purpose three member -(thiiranes) and four member-(thienthanes) cyclic compounds containing sulfur have been synthesized. As a result of the implemented investigations it has been established that when sulfur element is located in three – or four-member rings their anti-wear and anti-scuff features are higher than the same properties of other class sulfur-organic compounds.

The action mechanism of phenol, naphtol and sulfur derivatives of aromatic amines as oxidation inhibitors has been studied for the first time in the laboratory, the kinetic relationship of the elementary reactions of preventing oxidation processes of hydrocarbons by those inhibitors has been determined. It has been established that the stated antioxidants have combined influence, by repulsing the peroxide radicals they break the oxidation chain and by oxidizing to hydro-peroxides become substances which catalytically break hydro-peroxides into molecules and repulse a lot of peroxide radicals.

According to the results of the fundamental investigations, new and highly effective combined additives preventing oxidation of lubricating oils and fuels have been synthesized and synergetic compositions of high-performance antioxidants have been worked out.

The laboratory employees have given reports at many international and republic conferences, the young scientists have been involved in the exchange programs in leading scientific centers of foreign countries.

As a result of international joint research with leading experts from the Center for Computational  Research at the University of Buffalo, USA, through quantum-chemical calculations, the experimental-theoretical mechanism of three-component condensation reactions was studied in detail and confirmed by using the synthesis of 4,6-diphenyl-1,3,5-triazine- 2-thione through reaction of thiocarbamide, benzaldehyde and 33.5% aqueous solution of ammonia. According to the mechanism the reaction of ammonia with benzaldehyde, which begins with a nucleophilic attack, leads to the end product after 7 transit steps. In addition, the spatial and asymmetric isomeric forms of these compounds were studied in detail by  using x-ray diffraction analysis, and it was confirmed that this substance exists as a trans isomer.

It was shown that new derivatives of triazintions synthesized by the interaction of thiourea, aromatic aldehydes and amines have a strong anticholinergic and antidiabetic inhibitory effect on the enzymes  –  acetylcholinesterase (AChE) and α-glycosidase (α-Gly) in living organisms. The presence of several easily oxidizable functional groups in the molecule leads to their pharmacologic effectiveness which is 2-4 times higher than that of the standard drugs like Tacrine and ACR.

The laboratory has scientific relations with the Center for Computational Research at University of Buffalo, Institute of Biostructure and Bioimaging (IBB) of  Italian National Research Council, Institutes of Chemical Physics and Element Organic Compounds of the Academy of Sciences of Russia, Moscow State University, Moscow Academy of Fine Chemistry Technology, Middle East Technical, Hacettepe and Ataturk Universities of Turkey and Institute of Biochemistry of Bioactive Substances of the National Academy of Belarus.

5 doctors of science and 20 doctors of philosophy in chemistry have been trained in the laboratory, more than 1000 articles have been published and about 150 certifications of authorship and patents have been received.